With only a few matches remaining, the race for both the title and the Pichichi remains wide open. Lewandowski and Mbappe will push each other to the limit, knowing that every goal could be the difference between glory and disappointment.
Lewandowski scored his 20th goal of the season with a 28th-minute penalty that went in off the post.
Lewandowski suffered a back injury in Sunday's 1-0 defeat at Real Sociedad during which he had a goal controversially disallowed.
Lewandowski's early disallowed strike led to furious debate over whether the Polish forward had been offside or not.
It was another commanding victory for LaLiga leaders Barcelona who are in an imperious vein of form, scoring 24 goals in six successive wins in all competitions, including thrashings of Bayern Munich and Real Madrid.
Madrid beat Celta Vigo on Saturday to pull level with Hansi Flick's side but Barca swiftly restored their advantage with a stylish and dominant display of attacking football.
The 36-year-old hitman looks far sharper than last season and has 12 goals in 11 games across all competitions.
The Polish forward struck from close range in the first half to maintain Barca's 100 percent record in the league so far this season with their seventh victory.
Barcelona striker Robert Lewandowski would love Lionel Messi to return to the Catalan club from Paris Saint-Germain this summer, he said on Tuesday.
Bayern Munich star Robert Lewandowski revealed Tuesday he wants to call time on his career with the Bundesliga giants because of his desire for "more emotions in life".
Robert Lewandowski scored twice, including a stoppage-time winner as Bundesliga leaders Bayern Munich came from a goal down to beat Freiburg 2-1 on Friday and open up a six point lead as the league resumed after the winter break.
Robert Lewandowski scored a brilliant free kick to give Bayern Munich a 1-0 win over Atletico Madrid in their last Champions League Group D outing on Tuesday, ending the 100 percent record of their opponents.
German newspaper Bild reports that Borussia Dortmund defender and captain Mats Hummels is in talk with Bundesliga rivals Bayern Munich over a possible move there after his contract expires in 2017.