Iga Swiatek admits the strict doping protocols can be stressful for players but feels like she has "been through the worst" after surviving her positive test over contaminated melatonin.
Swiatek said she made far too many mistakes against Keys on Rod Laver Arena and hoped to draw lessons from it.
The Polish second seed was phenomenal on a gusty day at Rod Laver Arena, powering past the eighth seeded-American 6-1, 6-2 in 1hrs 29mins.
Romania's Simona Halep on Friday rounded on the International Tennis Integrity Agency (ITIA) for discrepencies in the treatment of world number two Iga Swiatek after testing positive for a banned substance.
"The player was provisionally suspended from Sept. 22 until Oct. 4, missing three tournaments, which counts towards the sanction, leaving eight days remaining," the ITIA said in a statement.
The 26-year-old jumped above Poland's French Open champion Iga Swiatek thanks to year-end adjustments in the standings.
Top seed Swiatek, who won the title two years ago, showcased her all-court game in a straightforward 6-4, 6-1 win over Russian Liudmila Samsonova to open the evening session at Arthur Ashe Stadium and warned she was only going to improve.
Four-time French Open champion Swiatek was equally dominant as Sinner as the top-seeded Pole eased into the fourth round with a 6-4, 6-2 victory over Russia's Anastasia Pavlyuchenkova.
World number one Iga Swiatek of Poland withdrew from next week's WTA event in Toronto on Friday, citing fatigue from her run to a bronze medal at the Paris Olympics.
On a cold and wet day at the All England Club, only three of the women's top 10 were left in the draw, while Andy Murray's Wimbledon career ended with a whimper when Emma Raducanu pulled the plug on their mixed doubles plans.
Seven-time champion Djokovic is chasing Roger Federer's record of eight titles at the All England Club and his 25th Grand Slam title in total.
The Polish has won five Grand Slams but has never progressed beyond the Wimbledon quarter-finals.
Iga Swiatek goes into Saturday's French Open final as the overwhelming favourite in her quest for a third successive Roland Garros title against surprise challenger Jasmine Paolini of Italy.
Iga Swiatek swept past Coco Gauff to reach the Rome Open final on Thursday where Aryna Sabalenka will stand in her way of a third title and her bid to match a Serena Williams record.
Top seed Swiatek, the 2022 and 2023 champion at the German clay-court tournament, saw off former US Open champion Raducanu 7-6 (7/2), 6-3.
Swiatek is the first player to win three straight titles at the same WTA event since Serena Williams completed a Miami Open hat-trick from 2013-15.
Top seed Iga Swiatek crashed out of the Australian Open on Saturday, losing 3-6, 6-3, 6-4 to Czech teenager Linda Noskova in the third round as her bid for a maiden Melbourne Park title and fifth Grand Slam trophy fell apart.
Iga Swiatek came back from the brink to beat unseeded American Danielle Collins in the second round of the Australian Open on Thursday, extending her winning run to 18 matches.
She enters the opening Grand Slam of the year as favourite.
