Nico O'Reilly added City's fifth in the 79th minute as the champions provisionally climbed to fourth in the table, two points ahead of fifth-placed Chelsea who have played a game less.
The English top flight needed just one win from its clubs in any of the three European competitions to secure one of two extra berths - on top of the four granted to the top four in the table - awarded to the highest-ranked countries in the UEFA coefficient ranking.
Pep Guardiola's team are fifth in the table on 52 points, one behind Chelsea, and United are languishing in 13th place on 38.
Liverpool remain top with 73 points from 31 games, 11 ahead of Arsenal. They need a maximum of 11 points from their remaining seven matches to win the title.
Second-placed Arsenal have 62 points from 31 games, 11 behind leaders Liverpool, who have a game at hand when they go to Fulham on Sunday. Everton climb to 14th place with 35 points from their 31 matches, 15 points clear of the relegation zone.
Tonali fired Newcastle into fifth place in the Premier League as the Italian midfielder's 74th-minute rocket beat Brentford goalkeeper Mark Flekken from an improbable angle.
Victory means Liverpool need just 13 points from their remaining eight games to be assured of a record-equalling 20th English top-flight title.
Former United winger Anthony Elanga came back to haunt his former club with a stunning solo effort after just five minutes at the City Ground to earn all three points for Nuno Espirito Santo's side.
The Premier League will use semi-automated offside technology for the first time in matches starting from April 12.
Nico O'Reilly added City's fifth in the 79th minute as the champions provisionally climbed to fourth in the table, two points ahead of fifth-placed Chelsea who have played a game less.
The English top flight needed just one win from its clubs in any of the three European competitions to secure one of two extra berths - on top of the four granted to the top four in the table - awarded to the highest-ranked countries in the UEFA coefficient ranking.
Pep Guardiola's team are fifth in the table on 52 points, one behind Chelsea, and United are languishing in 13th place on 38.
Liverpool remain top with 73 points from 31 games, 11 ahead of Arsenal. They need a maximum of 11 points from their remaining seven matches to win the title.
Second-placed Arsenal have 62 points from 31 games, 11 behind leaders Liverpool, who have a game at hand when they go to Fulham on Sunday. Everton climb to 14th place with 35 points from their 31 matches, 15 points clear of the relegation zone.
Tonali fired Newcastle into fifth place in the Premier League as the Italian midfielder's 74th-minute rocket beat Brentford goalkeeper Mark Flekken from an improbable angle.
Victory means Liverpool need just 13 points from their remaining eight games to be assured of a record-equalling 20th English top-flight title.
Former United winger Anthony Elanga came back to haunt his former club with a stunning solo effort after just five minutes at the City Ground to earn all three points for Nuno Espirito Santo's side.
The Premier League will use semi-automated offside technology for the first time in matches starting from April 12.
Everton boss David Moyes believes the gap between his side and Premier League leaders Liverpool has never been bigger as the Toffees prepare to travel to Anfield for Wednesday's Merseyside derby.
