US President Joe Biden suffered his first cabinet defeat Tuesday as he pulled an ill-fated nomination, the clearest signal yet that immensely powerful moderates in the deadlocked Senate can imperil his administration's ambitious agenda.  Biden was forced to abandon his push to make Neera Tanden the White House budget director after centrists on both sides of the political aisle made it clear they would not support her. Several other Biden picks have made it into their posts with bipartisan support, including Secretary of State Antony Blinken and Treasury Secretary Janet Yellen. Two more nominees were confirmed Tuesday: Council of Economic Advisors chair Cecilia Rouse, the first Black person to serve in the position, and Commerce Secretary Gina Raimondo.